Conventional radiotherapy is a routine palliative treatment for children with DIPG/DMG and provides a temporary reduction in symptoms. Children typically receive 30 treatments over 6 weeks. But conventional radiotherapy is not curative, and no other treatments are available. Microbeam radiation therapy is a novel, experimental radiotherapy in which X-rays are generated from a synchrotron. This form of radiotherapy delivers higher doses of radiation in a SINGLE treatment and the beams are shaped to reduce damage to the healthy tissues of the brain. A pilot study was funded to investigate its possible use as curative treatment for DIPG/DMG. It comprised a multidisciplinary group of scientists, including physicists, radiotherapists and cancer biologists. Results showed that doses 20 times higher than conventional radiotherapy could be delivered safely, a significant finding. The project was funded in partnership with RCD Foundation.